Neuronal Hyperexcitability: The Elusive But Modifiable Instigator of Disease

Despite enormous strides in medical diagnostics and the ability to analyze track disease processes, underlying cause of most psychiatric disorders remains unclear. Consequently, treatment these continues be more palliative than preventive. However, an emerging hypothesis contends that severe persistent stress is at root general conditions. Although this idea not new, what new identification a powerful but elusive endogenous driver stress. According Multi-Circuit Neuronal Hyperexcitability (MCNH) hypothesis, ordinary daily stressors are abnormally amplified by inherent hyperexcitability neurological system. This pathophysiological trait, which appears inherited autosomal dominant distribution expressed through central peripheral nervous systems, causes shockwaves repeatedly sent body, keeping it fight-or-flight mode much or all time. The strain commonly-occurring trait places on various organs systems body can repeated bouts mental illness gradual progression physical illnesses such as diabetes mellitus, high blood pressure, cardiovascular disease, autoimmune diseases, cancer, dementia. etiology thought multifactorial, genealogical they occur relationship have one another strongly suggests among psychological, biological, environmental factors contribute their development, neuronal important. observation has implications because highly modifiable risk factor. Any behavioral, dietary, intervention quiets system potentially prevent delay development fueled trait. In addition, there evidence detected resting vital-sign measurements. ease objective measurement power incentivize affected persons take control health underscores importance recognizing connection between pathogenesis disease.